LAC3_MOUSE
ID LAC3_MOUSE Reviewed; 104 AA.
AC P01845;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Ig lambda-3 chain C region;
GN Name=Iglc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6812053; DOI=10.1073/pnas.79.15.4681;
RA Selsing E., Miller J., Wilson R., Storb U.;
RT "Evolution of mouse immunoglobulin lambda genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:4681-4685(1982).
RN [2]
RP PROTEIN SEQUENCE OF 1-18 (MYELOMA PROTEIN CBPC-49).
RA Breyer R.M., Sauer R.T., Eisen H.N.;
RT "The variable region of mouse lambda-3 chains.";
RL ICN UCLA Symp. Mol. Cell. Biol. 20:105-110(1981).
RN [3]
RP PROTEIN SEQUENCE OF 10-104 (MYELOMA PROTEIN CBPC-49 AND MONOCLONAL ANTIBODY
RP 8-47).
RX PubMed=6165998; DOI=10.1073/pnas.78.1.569;
RA Azuma T., Steiner L.A., Eisen H.N.;
RT "Identification of a third type of lambda light chain in mouse
RT immunoglobulins.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:569-573(1981).
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DR EMBL; J00585; AAB59670.1; -; Genomic_DNA.
DR PIR; B93922; L3MS.
DR PIR; S22762; S22762.
DR AlphaFoldDB; P01845; -.
DR SMR; P01845; -.
DR MaxQB; P01845; -.
DR PeptideAtlas; P01845; -.
DR PRIDE; P01845; -.
DR ProteomicsDB; 263693; -.
DR MGI; MGI:99886; Iglc3.
DR InParanoid; P01845; -.
DR OMA; DHARECW; -.
DR PhylomeDB; P01845; -.
DR ChiTaRS; Iglc3; mouse.
DR PRO; PR:P01845; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01845; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Immunoglobulin domain;
KW Reference proteome.
FT CHAIN <1..104
FT /note="Ig lambda-3 chain C region"
FT /id="PRO_0000153610"
FT DOMAIN 6..99
FT /note="Ig-like"
FT DISULFID 27..85
FT DISULFID 103
FT /note="Interchain (with heavy chain)"
FT NON_TER 1
SQ SEQUENCE 104 AA; 11371 MW; 83CEBCD4AA348EF1 CRC64;
QPKSTPTLTM FPPSPEELQE NKATLVCLIS NFSPSGVTVA WKANGTPITQ GVDTSNPTKE
DNKYMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP AECL
