ID   ARCC2_STAES             Reviewed;         309 AA.
AC   Q8CU42;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Carbamate kinase 2;
DE            EC=2.7.2.2;
GN   Name=arcC2; OrderedLocusNames=SE_0102;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC       degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO03699.1; -; Genomic_DNA.
DR   RefSeq; NP_763657.1; NC_004461.1.
DR   RefSeq; WP_000036756.1; NZ_WBME01000039.1.
DR   AlphaFoldDB; Q8CU42; -.
DR   SMR; Q8CU42; -.
DR   STRING; 176280.SE_0102; -.
DR   EnsemblBacteria; AAO03699; AAO03699; SE_0102.
DR   GeneID; 50017522; -.
DR   KEGG; sep:SE_0102; -.
DR   PATRIC; fig|176280.10.peg.96; -.
DR   eggNOG; COG0549; Bacteria.
DR   HOGENOM; CLU_076278_0_0_9; -.
DR   OMA; ETTPYPM; -.
DR   UniPathway; UPA00996; UER00366.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN           1..309
FT                   /note="Carbamate kinase 2"
FT                   /id="PRO_0000185139"
SQ   SEQUENCE   309 AA;  33158 MW;  FB1B991A50FC2621 CRC64;
     MSKIVVALGG NALGQSPKEQ LDLLKSTSKS LVSLIDKGYE IVISHGNGPQ VGSINLGLNY
     AAEHKQGPPF PFPECGAMSQ AYIGYQMQES LQNELHSMGI DKEVVTLVTQ VQVASDDSAF
     NNPTKPIGLF YTKEQADKFT KEKGYTFVED SGRGYRRVVP SPQPISIVEL DSIETLITHG
     TLVIAAGGGG IPVIKENEVY TGVDAVIDKD KTSALLAAHL QSDQLIILTA VDHVYINYGK
     ENQRGLDEVS VDEMKKHISD GQFAKGSMLP KVEAALQFLE KNTKGSVLIT SLAGLGDALD
     GKIGTLIKN