ID   LACA_STRA1              Reviewed;         141 AA.
AC   Q3JZ18;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN   Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=SAK_1890;
OS   Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS   SS700).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=205921;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27591 / A909 / CDC SS700;
RX   PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA   Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T.,
RA   Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D.,
RA   Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M.,
RA   Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H.,
RA   Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D.,
RA   Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O.,
RA   Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L.,
RA   Wessels M.R., Rappuoli R., Fraser C.M.;
RT   "Genome analysis of multiple pathogenic isolates of Streptococcus
RT   agalactiae: implications for the microbial 'pan-genome'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01555};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01555}.
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DR   EMBL; CP000114; ABA44592.1; -; Genomic_DNA.
DR   RefSeq; WP_000152527.1; NC_007432.1.
DR   AlphaFoldDB; Q3JZ18; -.
DR   SMR; Q3JZ18; -.
DR   KEGG; sak:SAK_1890; -.
DR   HOGENOM; CLU_091396_4_2_9; -.
DR   OMA; AHNNARI; -.
DR   UniPathway; UPA00702; UER00714.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01555; LacA; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01118; lacA; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..141
FT                   /note="Galactose-6-phosphate isomerase subunit LacA"
FT                   /id="PRO_0000208115"
SQ   SEQUENCE   141 AA;  15315 MW;  660F0F8495B79F2A CRC64;
     MTIIIGADAH GVELKEVIRQ HLTSLGKEII DLTDTSKDFV DNTLAIVAKV NQKEDNLGIM
     VDAYGVGPFM VATKVKGMIA AEVSDERSAY MTRAHNNARM ITLGSEIVGP GVAKHIVEGF
     VDGTYDAGRH QIRVDMLNKM C