ID   LACA_STRMU              Reviewed;         142 AA.
AC   P26423;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN   Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=SMU_1496;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1400164; DOI=10.1128/jb.174.19.6159-6170.1992;
RA   Rosey E.L., Stewart G.C.;
RT   "Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and
RT   lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and
RT   sugar-specific phosphotransferase system components of the lactose operon
RT   of Streptococcus mutans.";
RL   J. Bacteriol. 174:6159-6170(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01555};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01555}.
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DR   EMBL; M80797; AAA26904.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59150.1; -; Genomic_DNA.
DR   PIR; C43258; C43258.
DR   RefSeq; NP_721844.1; NC_004350.2.
DR   RefSeq; WP_002262463.1; NC_004350.2.
DR   AlphaFoldDB; P26423; -.
DR   SMR; P26423; -.
DR   STRING; 210007.SMU_1496; -.
DR   PRIDE; P26423; -.
DR   EnsemblBacteria; AAN59150; AAN59150; SMU_1496.
DR   GeneID; 66819104; -.
DR   KEGG; smu:SMU_1496; -.
DR   PATRIC; fig|210007.7.peg.1332; -.
DR   eggNOG; COG0698; Bacteria.
DR   HOGENOM; CLU_091396_4_2_9; -.
DR   OMA; AMHNGAK; -.
DR   PhylomeDB; P26423; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01555; LacA; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01118; lacA; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Galactose-6-phosphate isomerase subunit LacA"
FT                   /id="PRO_0000208119"
SQ   SEQUENCE   142 AA;  15608 MW;  58329E8DD717AEFF CRC64;
     MAIIIGSDAA GKRLKDVIKT FLKDNNHEVL DVTERKDLDF VDSTLAVVHE VQKNDKNLGI
     AIDAYGAGSF MVATKVKGMI AAEVSDERSA YMTRGHNNAR IITLGAEIVG DELAKNIVKD
     FVEAKYDGGR HQIRVDMLNK MC