ID   LACA_STRP2              Reviewed;         141 AA.
AC   Q04KC1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN   Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=SPD_1053;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01555};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01555}.
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DR   EMBL; CP000410; ABJ54186.1; -; Genomic_DNA.
DR   RefSeq; WP_000029272.1; NC_008533.2.
DR   AlphaFoldDB; Q04KC1; -.
DR   SMR; Q04KC1; -.
DR   STRING; 373153.SPD_1053; -.
DR   EnsemblBacteria; ABJ54186; ABJ54186; SPD_1053.
DR   GeneID; 60233790; -.
DR   GeneID; 66806314; -.
DR   KEGG; spd:SPD_1053; -.
DR   eggNOG; COG0698; Bacteria.
DR   HOGENOM; CLU_091396_4_2_9; -.
DR   OMA; AMHNGAK; -.
DR   OrthoDB; 1346802at2; -.
DR   BioCyc; SPNE373153:G1G6V-1144-MON; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01555; LacA; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01118; lacA; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..141
FT                   /note="Galactose-6-phosphate isomerase subunit LacA"
FT                   /id="PRO_1000068924"
SQ   SEQUENCE   141 AA;  15244 MW;  BF0C9F8FAF1445A9 CRC64;
     MSIVIGADAA GLRLKEVVKD FLEKENFHLV DVTAEGQDFV DVTLAVAAEV NKEEQNLGIV
     IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNSRM ITMGAQLVGD ELAKNIAKGF
     VNGKYDGGRH QIRVDMLNKM G