ID   LACA_STRS7              Reviewed;         141 AA.
AC   C0MDX6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN   Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=SZO_15290;
OS   Streptococcus equi subsp. zooepidemicus (strain H70).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H70;
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA   Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA   Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA   Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA   Maskell D.J., Parkhill J., Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01555};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01555}.
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DR   EMBL; FM204884; CAX00210.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0MDX6; -.
DR   SMR; C0MDX6; -.
DR   PRIDE; C0MDX6; -.
DR   EnsemblBacteria; CAX00210; CAX00210; SZO_15290.
DR   KEGG; seq:SZO_15290; -.
DR   eggNOG; COG0698; Bacteria.
DR   HOGENOM; CLU_091396_4_2_9; -.
DR   OMA; RCAIVSE; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000001368; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01555; LacA; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01118; lacA; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..141
FT                   /note="Galactose-6-phosphate isomerase subunit LacA"
FT                   /id="PRO_1000215501"
SQ   SEQUENCE   141 AA;  15263 MW;  0FAE454B46A0AF03 CRC64;
     MAIILGADAH GNELKEVLKG FLQQEGFDVT DVTDIDKDFI DNTLAVAQAV NDKDTNLGIM
     VDAYGAGPFM VATKLKGMIA AEVSDERSAY MTRGHNNARM MTMGAEIVGQ ELAKNIAKGF
     VTGHYDGGRH QIRVDMLNKM A