ID   LACB1_CANLF             Reviewed;         161 AA.
AC   P33685;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Beta-lactoglobulin-1;
DE            Short=Beta-LG-1;
DE   AltName: Full=Beta-lactoglobulin I;
GN   Name=LGB1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Halliday J.A., Bell K., McAndrew K., Shaw D.C.;
RT   "Feline beta-lactoglobulins I, II and III, and canine beta-lactoglobulins I
RT   and II: amino acid sequences provide evidence for the existence of more
RT   than one gene for beta-lactoglobulin in the cat and dog.";
RL   Protein Seq. Data Anal. 5:201-205(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF N-TERMINUS, AND CHARACTERIZATION.
RC   STRAIN=Beagle;
RX   PubMed=3707136; DOI=10.1016/0003-9861(86)90341-3;
RA   Pervaiz S., Brew K.;
RT   "Purification and characterization of the major whey proteins from the
RT   milks of the bottlenose dolphin (Tursiops truncatus), the Florida manatee
RT   (Trichechus manatus latirostris), and the beagle (Canis familiaris).";
RL   Arch. Biochem. Biophys. 246:846-854(1986).
CC   -!- FUNCTION: Primary component of whey, it binds retinol and is probably
CC       involved in the transport of that molecule.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized in mammary gland and secreted in milk.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   PIR; S33877; S33877.
DR   AlphaFoldDB; P33685; -.
DR   SMR; P33685; -.
DR   STRING; 9612.ENSCAFP00000029239; -.
DR   PaxDb; P33685; -.
DR   eggNOG; ENOG502T0EI; Eukaryota.
DR   InParanoid; P33685; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR002447; Blactoglobulin.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01172; BLCTOGLOBULN.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein;
KW   Reference proteome; Retinol-binding; Secreted; Transport.
FT   CHAIN           1..161
FT                   /note="Beta-lactoglobulin-1"
FT                   /id="PRO_0000201013"
FT   DISULFID        66..159
FT                   /evidence="ECO:0000250"
FT   DISULFID        106..119
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   161 AA;  18567 MW;  BB775CC5F54332E6 CRC64;
     IVVPRTMEDL DLQKVAGTWH SMAMAASDIS LLDSETAPLR VYIQELRPTP QDNLEIVLRK
     WEDGRCAEQK VLAEKTEVPA EFKINYVEEN QIFLLDTDYD NYLFFCEMNA DAPQQSLMCQ
     CLARTLEVDN EVMEKFNRAL KTLPVHMQLL NPTQAEEQCL I