ID   LACB1_EQUAS             Reviewed;         162 AA.
AC   P13613;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Beta-lactoglobulin-1;
DE            Short=Beta-LG-1;
DE   AltName: Full=Beta-lactoglobulin I, major monomeric;
GN   Name=LGB1;
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Milk;
RX   PubMed=3370127; DOI=10.1515/bchm3.1988.369.1.171;
RA   Godovac-Zimmermann J., Conti A., James L., Napolitano L.;
RT   "Microanalysis of the amino-acid sequence of monomeric beta-lactoglobulin I
RT   from donkey (Equus asinus) milk. The primary structure and its homology
RT   with a superfamily of hydrophobic molecule transporters.";
RL   Biol. Chem. Hoppe-Seyler 369:171-179(1988).
CC   -!- FUNCTION: Primary component of whey, it binds retinol and is probably
CC       involved in the transport of that molecule.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized in mammary gland and secreted in milk.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   PIR; S00372; LGHOD.
DR   AlphaFoldDB; P13613; -.
DR   SMR; P13613; -.
DR   PRIDE; P13613; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR002447; Blactoglobulin.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01172; BLCTOGLOBULN.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein; Retinol-binding;
KW   Secreted; Transport.
FT   CHAIN           1..162
FT                   /note="Beta-lactoglobulin-1"
FT                   /id="PRO_0000201015"
FT   DISULFID        66..160
FT   DISULFID        106..119
SQ   SEQUENCE   162 AA;  18528 MW;  AA369B362D306C7C CRC64;
     TNIPQTMQDL DLQEVAGKWH SVAMAASDIS LLDSEEAPLR VYIEKLRPTP EDNLEIILRE
     GENKGCAEKK IFAEKTESPA EFKINYLDED TVFALDSDYK NYLFLCMKNA ATPGQSLVCQ
     YLARTQMVDE EIMEKFRRAL QPLPGRVQIV PDLTRMAERC RI