LACB2_CAEEL
ID LACB2_CAEEL Reviewed; 295 AA.
AC Q95Q18; A5PEY5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Beta-lactamase-like protein 2 homolog;
DE EC=3.-.-.-;
GN ORFNames=Y53F4B.39;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q95Q18-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q95Q18-2; Sequence=VSP_030694;
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family. {ECO:0000305}.
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DR EMBL; AL132949; CAB61094.1; -; Genomic_DNA.
DR EMBL; AL132949; CAN99706.1; -; Genomic_DNA.
DR RefSeq; NP_001122663.1; NM_001129191.2. [Q95Q18-2]
DR RefSeq; NP_497107.1; NM_064706.3. [Q95Q18-1]
DR AlphaFoldDB; Q95Q18; -.
DR SMR; Q95Q18; -.
DR BioGRID; 40437; 9.
DR STRING; 6239.Y53F4B.39b; -.
DR EPD; Q95Q18; -.
DR PaxDb; Q95Q18; -.
DR PeptideAtlas; Q95Q18; -.
DR EnsemblMetazoa; Y53F4B.39a.1; Y53F4B.39a.1; WBGene00013176. [Q95Q18-1]
DR EnsemblMetazoa; Y53F4B.39b.1; Y53F4B.39b.1; WBGene00013176. [Q95Q18-2]
DR GeneID; 175161; -.
DR KEGG; cel:CELE_Y53F4B.39; -.
DR UCSC; Y53F4B.39b; c. elegans. [Q95Q18-1]
DR CTD; 175161; -.
DR WormBase; Y53F4B.39a; CE24418; WBGene00013176; -. [Q95Q18-1]
DR WormBase; Y53F4B.39b; CE41183; WBGene00013176; -. [Q95Q18-2]
DR eggNOG; KOG0813; Eukaryota.
DR GeneTree; ENSGT00390000001710; -.
DR HOGENOM; CLU_048478_1_2_1; -.
DR InParanoid; Q95Q18; -.
DR OMA; EFYLAHR; -.
DR OrthoDB; 576967at2759; -.
DR PhylomeDB; Q95Q18; -.
DR PRO; PR:Q95Q18; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013176; Expressed in larva and 3 other tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR041516; LACTB2_WH.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF17778; BLACT_WH; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; SSF56281; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..295
FT /note="Beta-lactamase-like protein 2 homolog"
FT /id="PRO_0000315749"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 81
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 84
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 141
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 160
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 160
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 195
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1
FT /note="M -> MTAYVGRAWTMLRFYTDFAYAGVAYLVNSKAHRAM (in isoform
FT b)"
FT /evidence="ECO:0000305"
FT /id="VSP_030694"
SQ SEQUENCE 295 AA; 33103 MW; 5D798FC5C67B97CB CRC64;
MPSLTHVEPI EKLSDAVTRI LGHNPGPFTL QGTNTYLLGT GAKKILVDTG EPNVTEYISA
LKSVLASTNS HIEYIVITHW HGDHVGGIDN ITDEILDKKK IPIYKMKRDK DEGVERFHYV
DDGFEVAVDG ATLKLIATPG HTADHFSLWL QEERALFSGD CILGEGTTVF EDLHDYMTSL
QKIKDLNATR IYPGHGPVID KVVEKVDEYI EHRMKREREI IKVLKEHEEI TSMDVTNQVY
ADSPWAVRLA ALNNVKLVLK KLCKDGVVEN PHFETFKWIG GSSSGEEKKN ESSNL
