LACB2_STRP1
ID LACB2_STRP1 Reviewed; 171 AA.
AC Q99Y13; Q48WM0;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB 2 {ECO:0000255|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN Name=lacB2 {ECO:0000255|HAMAP-Rule:MF_01556}; Synonyms=lacB.2;
GN OrderedLocusNames=SPy_1922, M5005_Spy1637;
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX PubMed=16088826; DOI=10.1086/432514;
RA Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA Musser J.M.;
RT "Evolutionary origin and emergence of a highly successful clone of serotype
RT M1 group A Streptococcus involved multiple horizontal gene transfer
RT events.";
RL J. Infect. Dis. 192:771-782(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01556}.
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DR EMBL; AE004092; AAK34625.1; -; Genomic_DNA.
DR EMBL; CP000017; AAZ52255.1; -; Genomic_DNA.
DR RefSeq; NP_269904.1; NC_002737.2.
DR AlphaFoldDB; Q99Y13; -.
DR SMR; Q99Y13; -.
DR STRING; 1314.HKU360_01760; -.
DR PaxDb; Q99Y13; -.
DR EnsemblBacteria; AAK34625; AAK34625; SPy_1922.
DR KEGG; spy:SPy_1922; -.
DR KEGG; spz:M5005_Spy1637; -.
DR PATRIC; fig|160490.10.peg.1670; -.
DR HOGENOM; CLU_091396_2_0_9; -.
DR OMA; CCWTGTG; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; -; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR PANTHER; PTHR30345; PTHR30345; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; SSF89623; 1.
DR TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism; Reference proteome.
FT CHAIN 1..171
FT /note="Galactose-6-phosphate isomerase subunit LacB 2"
FT /id="PRO_0000208154"
SQ SEQUENCE 171 AA; 18893 MW; 3253828AA1A30238 CRC64;
MKIAVGCDHI VTYEKIAVVD YLKSQGHKVI DCGTYDNVRT HYPIFGKKVG EAVASGEAEL
GVVICGTGVG ITNAVNKVPG IRSALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII
DAFLAAEYKP TEENKKWIEK MDSLQHASQD QNNPHFFDEF LEKWDRGEYH D