LACB2_STRP6
ID LACB2_STRP6 Reviewed; 171 AA.
AC Q5X9Y2;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB 2 {ECO:0000255|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN Name=lacB2 {ECO:0000255|HAMAP-Rule:MF_01556}; OrderedLocusNames=M6_Spy1646;
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394;
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01556}.
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DR EMBL; CP000003; AAT87781.1; -; Genomic_DNA.
DR RefSeq; WP_011184966.1; NC_006086.1.
DR AlphaFoldDB; Q5X9Y2; -.
DR SMR; Q5X9Y2; -.
DR EnsemblBacteria; AAT87781; AAT87781; M6_Spy1646.
DR KEGG; spa:M6_Spy1646; -.
DR HOGENOM; CLU_091396_2_0_9; -.
DR OMA; CCWTGTG; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; -; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR PANTHER; PTHR30345; PTHR30345; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; SSF89623; 1.
DR TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism.
FT CHAIN 1..171
FT /note="Galactose-6-phosphate isomerase subunit LacB 2"
FT /id="PRO_0000208162"
SQ SEQUENCE 171 AA; 18934 MW; 9AFDD00133B0302D CRC64;
MKIAVGCDHI VTYEKIAVVD YLKSQGHKVI DCGTYDNVRT HYPIFGKKVG EAVASGKAEL
GVVICGTGVG ITNAVNKVPG IRAALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII
DAFLAAEYKP TEENKKWIEK MDSLQHTNQD QNNPHFFDEF LEKWDRGEYH D