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LACB2_STRPQ
ID   LACB2_STRPQ             Reviewed;         171 AA.
AC   P0DC11; Q79W96; Q8K5U7;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacB 2 {ECO:0000255|HAMAP-Rule:MF_01556};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN   Name=lacB2 {ECO:0000255|HAMAP-Rule:MF_01556}; Synonyms=lacB.2;
GN   OrderedLocusNames=SPs1656;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01556};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01556}.
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DR   EMBL; BA000034; BAC64751.1; -; Genomic_DNA.
DR   RefSeq; WP_011055005.1; NC_004606.1.
DR   AlphaFoldDB; P0DC11; -.
DR   SMR; P0DC11; -.
DR   KEGG; sps:SPs1656; -.
DR   HOGENOM; CLU_091396_2_0_9; -.
DR   OMA; CCWTGTG; -.
DR   UniPathway; UPA00702; UER00714.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01556; LacB; 1.
DR   InterPro; IPR004784; LacB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..171
FT                   /note="Galactose-6-phosphate isomerase subunit LacB 2"
FT                   /id="PRO_0000411393"
SQ   SEQUENCE   171 AA;  18922 MW;  7B7C225FC7E7DC00 CRC64;
     MKIAVGCDHI VTYEKIAVVD YLKTQGHEII DCGTYDNVRT HYPIFGKKVG EAVASGEAEL
     GVVICGTGVG ITNAVNKVPG IRSALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII
     DAFLAAEYKP TEENKKWIEK MDSLQHASQD QNNPHFFDEF LEKWDRGEYH D
 
 
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