ID   ARCC_HAEIN              Reviewed;         310 AA.
AC   P44769;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
GN   Name=arcC; OrderedLocusNames=HI_0595;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC       degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22252.1; -; Genomic_DNA.
DR   PIR; G64079; G64079.
DR   RefSeq; NP_438752.1; NC_000907.1.
DR   RefSeq; WP_005694569.1; NC_000907.1.
DR   AlphaFoldDB; P44769; -.
DR   SMR; P44769; -.
DR   STRING; 71421.HI_0595; -.
DR   EnsemblBacteria; AAC22252; AAC22252; HI_0595.
DR   KEGG; hin:HI_0595; -.
DR   PATRIC; fig|71421.8.peg.616; -.
DR   eggNOG; COG0549; Bacteria.
DR   HOGENOM; CLU_076278_0_1_6; -.
DR   OMA; QPMDVAG; -.
DR   PhylomeDB; P44769; -.
DR   BioCyc; HINF71421:G1GJ1-605-MON; -.
DR   UniPathway; UPA00996; UER00366.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IBA:GO_Central.
DR   GO; GO:0019546; P:arginine deiminase pathway; IBA:GO_Central.
DR   GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..310
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185125"
SQ   SEQUENCE   310 AA;  33440 MW;  E86DB86848377425 CRC64;
     MRIVIALGGN ALLRRGEPMT AENQRQNVRI ACEQIAKIWP NNELVIAHGN GPQVGLLALQ
     GAAYTDVPTY PLDVLGAETA GMIGYMIQQE LGNLVPFEVP FATLLSQVEV DINDPAFKNP
     TKPIGPVYTK EEAERLAKEK NWSIAQDGDK YRRVVPSPLP KRIFEIRPVK WLLEKGSIVI
     CAGGGGIPTY YDEHHNLQGV EAVIDKDLCS ALLAENLDAD LFIIATDVSA TFVDWGKPNQ
     KAISVASPEA ISELGFASGS MGPKVQAAIN FAKQTGKDAV IGSLSDIVDI VKGKAGTRIT
     KKTEGISYYA