ID   LACB3_FELCA             Reviewed;         162 AA.
AC   P33688;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Beta-lactoglobulin-3;
DE            Short=Beta-LG-3;
DE   AltName: Full=Beta-lactoglobulin III;
GN   Name=LGB3;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Halliday J.A., Bell K., McAndrew K., Shaw D.C.;
RT   "Feline beta-lactoglobulins I, II and III, and canine beta-lactoglobulins I
RT   and II: amino acid sequences provide evidence for the existence of more
RT   than one gene for beta-lactoglobulin in the cat and dog.";
RL   Protein Seq. Data Anal. 5:201-205(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-24.
RC   TISSUE=Milk;
RX   PubMed=2344734; DOI=10.1016/0305-0491(90)90316-l;
RA   Halliday J.A., Bell K., McKenzie H.A., Shaw D.C.;
RT   "Feline whey proteins: identification, isolation and initial
RT   characterization of alpha-lactalbumin, beta-lactoglobulin and lysozyme.";
RL   Comp. Biochem. Physiol. 95B:773-779(1990).
CC   -!- FUNCTION: Lactoglobulin is the primary component of whey, it binds
CC       retinol and is probably involved in the transport of that molecule.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   PIR; S33876; S33876.
DR   AlphaFoldDB; P33688; -.
DR   SMR; P33688; -.
DR   InParanoid; P33688; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR002447; Blactoglobulin.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01172; BLCTOGLOBULN.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein;
KW   Reference proteome; Retinol-binding; Secreted; Transport.
FT   CHAIN           1..162
FT                   /note="Beta-lactoglobulin-3"
FT                   /id="PRO_0000201019"
FT   DISULFID        66..160
FT                   /evidence="ECO:0000250"
FT   DISULFID        106..119
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  18657 MW;  53AA8E8A9E8094DA CRC64;
     ATVPLTMDGL DLQKVAGTWH SMAMAASDIS LLDSEYAPLR VYVQELRPTP RDNLEIILRK
     WEQKRCVQKK ILAQKTELPA EFKISYLDEN ELIVLDTDYE NYLFFCLENA DAPGQNLVCQ
     CLTRTLKADN EVMEKFDRAL QTLPVDVRLF FDPTQVAEQC RI