ID   LACB_CLOAB              Reviewed;         173 AA.
AC   Q97F02;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN   Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556}; OrderedLocusNames=CA_C2953;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01556};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01556}.
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DR   EMBL; AE001437; AAK80895.1; -; Genomic_DNA.
DR   PIR; D97263; D97263.
DR   RefSeq; NP_349555.1; NC_003030.1.
DR   RefSeq; WP_010966236.1; NC_003030.1.
DR   AlphaFoldDB; Q97F02; -.
DR   SMR; Q97F02; -.
DR   STRING; 272562.CA_C2953; -.
DR   EnsemblBacteria; AAK80895; AAK80895; CA_C2953.
DR   GeneID; 44999441; -.
DR   KEGG; cac:CA_C2953; -.
DR   PATRIC; fig|272562.8.peg.3137; -.
DR   eggNOG; COG0698; Bacteria.
DR   HOGENOM; CLU_091396_2_0_9; -.
DR   OMA; ETHHANQ; -.
DR   OrthoDB; 1346802at2; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01556; LacB; 1.
DR   InterPro; IPR004784; LacB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism; Reference proteome.
FT   CHAIN           1..173
FT                   /note="Galactose-6-phosphate isomerase subunit LacB"
FT                   /id="PRO_0000208132"
SQ   SEQUENCE   173 AA;  18951 MW;  8275B0B016B6D429 CRC64;
     MVISIGCDHI VPDIKMKISE YLKSKGHTVI DNGTYDFVRT HYPIFGKAAA EKVASGEADL
     GVILCGTGVG ISNSANKVKG IRAALVRDVG TARYAKEYLN ANVIAVGGRI TGIGLIENII
     DVFLEAKYKP TKENQEIIKG IDELIENDKG QFGNEHFFDE FIEKWDNGGY PKE