LACB_LACLL
ID LACB_LACLL Reviewed; 171 AA.
AC P23495;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556};
OS Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG Plasmid pLP712.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1360;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, OPERON STRUCTURE, AND
RP INDUCTION.
RC STRAIN=MG1820;
RX PubMed=1901863; DOI=10.1016/s0021-9258(20)89626-4;
RA van Rooijen R.J., van Schalkwijk S., de Vos W.M.;
RT "Molecular cloning, characterization, and nucleotide sequence of the
RT tagatose 6-phosphate pathway gene cluster of the lactose operon of
RT Lactococcus lactis.";
RL J. Biol. Chem. 266:7176-7181(1991).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01556, ECO:0000269|PubMed:1901863}.
CC -!- INDUCTION: By lactose. The operon consists of lacABCDFEGX.
CC {ECO:0000269|PubMed:1901863}.
CC -!- MISCELLANEOUS: This gene was sequenced from pMG820, a laboratory-
CC derived deletion of the naturally occurring plasmid pLP712.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01556}.
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DR EMBL; M60447; AAA25178.1; -; Genomic_DNA.
DR EMBL; M65190; AAA25169.1; -; Genomic_DNA.
DR PIR; B39778; B39778.
DR RefSeq; YP_005863085.1; NC_017478.1.
DR AlphaFoldDB; P23495; -.
DR SMR; P23495; -.
DR KEGG; ag:AAA25178; -.
DR BRENDA; 5.3.1.26; 2903.
DR UniPathway; UPA00702; UER00714.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; -; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR PANTHER; PTHR30345; PTHR30345; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; SSF89623; 1.
DR TIGRFAMs; TIGR01119; lacB; 1.
DR TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE 1: Evidence at protein level;
KW Isomerase; Lactose metabolism; Plasmid.
FT CHAIN 1..171
FT /note="Galactose-6-phosphate isomerase subunit LacB"
FT /id="PRO_0000208135"
SQ SEQUENCE 171 AA; 18926 MW; BE323E0690CEAE13 CRC64;
MRIAIGCDHI VTDVKMAVSE FLKSKGYEVL DFGTYDHVRT HYPIYGKKVG EAVVSGQADL
GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN ANVIGFGGMI TGGLLMNDII
EAFIEAEYKP TEENKKLIAK IEHVETHNAH QADEEFFTEF LEKWDRGEYH D