ID   LACB_MACGI              Reviewed;         155 AA.
AC   P11944;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Beta-lactoglobulin;
DE            Short=Beta-LG;
GN   Name=LGB;
OS   Macropus giganteus (Eastern gray kangaroo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Macropus.
OX   NCBI_TaxID=9317;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3620116; DOI=10.1515/bchm3.1987.368.2.879;
RA   Godovac-Zimmermann J., Shaw D.;
RT   "Beta-lactoglobulin identified in marsupial milk. The primary structure,
RT   binding site and possible function of beta-lactoglobulin from eastern grey
RT   kangaroo (Macropus giganteus).";
RL   Biol. Chem. Hoppe-Seyler 368:879-886(1987).
CC   -!- FUNCTION: Lactoglobulin is the primary component of whey, it binds
CC       retinol and is probably involved in the transport of that molecule.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   PIR; A29699; A29699.
DR   AlphaFoldDB; P11944; -.
DR   SMR; P11944; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein; Retinol-binding;
KW   Secreted; Transport.
FT   CHAIN           1..155
FT                   /note="Beta-lactoglobulin"
FT                   /id="PRO_0000201020"
FT   DISULFID        61..153
FT                   /evidence="ECO:0000250"
FT   DISULFID        103..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   155 AA;  18340 MW;  7BD7EA4A191530E5 CRC64;
     VENIRSKNDL GVEKFVGSWY LREAAKTMEF SIPLFDMDIK EVNLTPEGNL ELVLLEKTDR
     CVEKKLLLKK TKKPTEFEIY ISSESSYTFC VMETDYDSYF LFCLYNISDR EKMACAHYVR
     RIEENKGMNE FKKILRTLAM PYTVIEVRTR DMCHV