ID   LACB_NOTEU              Reviewed;         174 AA.
AC   Q29614;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Beta-lactoglobulin;
DE            Short=Beta-LG;
DE   Flags: Precursor;
GN   Name=LGB; Synonyms=BLG;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1707629; DOI=10.1677/jme.0.0060009;
RA   Collet C., Joseph R., Nicholas K.R.;
RT   "A marsupial beta-lactoglobulin gene: characterization and prolactin-
RT   dependent expression.";
RL   J. Mol. Endocrinol. 6:9-16(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7794241; DOI=10.1007/bf00554559;
RA   Collet C., Joseph R.;
RT   "Exon organization and sequence of the genes encoding alpha-lactalbumin and
RT   beta-lactoglobulin from the tammar wallaby (Macropodidae, Marsupialia).";
RL   Biochem. Genet. 33:61-72(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 47-174.
RC   TISSUE=Mammary gland;
RX   PubMed=7993373; DOI=10.1007/bf00554621;
RA   Collet C., Joseph R.;
RT   "The identification of nuclear and mitochondrial genes by sequencing
RT   randomly chosen clones from a marsupial mammary gland cDNA library.";
RL   Biochem. Genet. 32:181-190(1994).
CC   -!- FUNCTION: Lactoglobulin is the primary component of whey, it binds
CC       retinol and is probably involved in the transport of that molecule.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; L14959; AAA31597.1; -; Genomic_DNA.
DR   EMBL; L14954; AAA31597.1; JOINED; Genomic_DNA.
DR   EMBL; L14955; AAA31597.1; JOINED; Genomic_DNA.
DR   EMBL; L14956; AAA31597.1; JOINED; Genomic_DNA.
DR   EMBL; L14957; AAA31597.1; JOINED; Genomic_DNA.
DR   EMBL; L14958; AAA31597.1; JOINED; Genomic_DNA.
DR   EMBL; X15212; CAA33282.1; -; mRNA.
DR   AlphaFoldDB; Q29614; -.
DR   SMR; Q29614; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Milk protein; Retinol-binding; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..174
FT                   /note="Beta-lactoglobulin"
FT                   /id="PRO_0000017908"
FT   DISULFID        79..172
FT                   /evidence="ECO:0000250"
FT   DISULFID        122..134
FT                   /evidence="ECO:0000250"
FT   CONFLICT        76
FT                   /note="A -> T (in Ref. 3; CAA33282)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   174 AA;  20220 MW;  6C5901051F99C991 CRC64;
     MKFLLLTVGL ALIGAIQAVE NIRSKNDLGV EKFVGSWYLR EAAKTMEFSI PLFDMDIKEV
     NLTPEGNLEL VLLEKADRCV EKKLLLKKTQ KPTEFEIYIS SESASYTFSV METDYDSYFL
     FCLYNISDRE KMACAHYVRR IEENKGMNEF KKILRTLAMP YTVIEVRTRD MCHV