ID   LACB_OVIMU              Reviewed;         162 AA.
AC   P67975; P02757;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Beta-lactoglobulin;
DE            Short=Beta-LG;
GN   Name=LGB;
OS   Ovis aries musimon (Mouflon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9938;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3426802; DOI=10.1515/bchm3.1987.368.2.1313;
RA   Godovac-Zimmermann J., Conti A., Napolitano L.;
RT   "The complete amino-acid sequence of dimeric beta-lactoglobulin from
RT   mouflon (Ovis ammon musimon) milk.";
RL   Biol. Chem. Hoppe-Seyler 368:1313-1319(1987).
CC   -!- FUNCTION: Lactoglobulin is the primary component of whey, it binds
CC       retinol and is probably involved in the transport of that molecule.
CC   -!- SUBUNIT: Under physiological conditions beta-lactoglobulin exists as an
CC       equilibrium mixture of monomeric and dimeric forms.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Alternate disulfide bonds occur in equal amounts.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P67975; -.
DR   SMR; P67975; -.
DR   PRIDE; P67975; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR002447; Blactoglobulin.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01172; BLCTOGLOBULN.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Milk protein; Retinol-binding;
KW   Secreted; Transport.
FT   CHAIN           1..162
FT                   /note="Beta-lactoglobulin"
FT                   /id="PRO_0000201021"
FT   DISULFID        66..160
FT   DISULFID        106..121
FT                   /note="Alternate"
FT   DISULFID        106..119
SQ   SEQUENCE   162 AA;  18151 MW;  3902B2E4609CC991 CRC64;
     IIVTQTMKGL DIQKVAGTWH SLAMAASDIS LLDAQSAPLR VYVEELKPTP EGNLEILLQK
     WENGECAQKK IIAEKTKIPA VFKIDALNEN KVLVLDTDYK KYLLFCMENS AEPEQSLACQ
     CLVRTPEVDN EALEKFDKAL KALPMHIRLA FNPTQLEGQC HV