ID   LACB_STAA8              Reviewed;         171 AA.
AC   Q2G2R0; P26592; P68796;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN   Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556};
GN   OrderedLocusNames=SAOUHSC_02454;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-171.
RX   PubMed=2543958; DOI=10.1093/nar/17.10.3980;
RA   Rosey E.L., Stewart G.C.;
RT   "The nucleotide sequence of the lacC and lacD genes of Staphylococcus
RT   aureus.";
RL   Nucleic Acids Res. 17:3980-3980(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01556};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01556}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000253; ABD31474.1; -; Genomic_DNA.
DR   EMBL; X14827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B38158; B38158.
DR   RefSeq; WP_000684746.1; NZ_LS483365.1.
DR   RefSeq; YP_500921.1; NC_007795.1.
DR   AlphaFoldDB; Q2G2R0; -.
DR   SMR; Q2G2R0; -.
DR   STRING; 1280.SAXN108_2447; -.
DR   EnsemblBacteria; ABD31474; ABD31474; SAOUHSC_02454.
DR   GeneID; 3919017; -.
DR   KEGG; sao:SAOUHSC_02454; -.
DR   PATRIC; fig|93061.5.peg.2213; -.
DR   eggNOG; COG0698; Bacteria.
DR   HOGENOM; CLU_091396_2_0_9; -.
DR   OMA; ETHHANQ; -.
DR   UniPathway; UPA00702; UER00714.
DR   PRO; PR:Q2G2R0; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IBA:GO_Central.
DR   GO; GO:0019316; P:D-allose catabolic process; IBA:GO_Central.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01556; LacB; 1.
DR   InterPro; IPR004784; LacB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01119; lacB; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Galactose-6-phosphate isomerase subunit LacB"
FT                   /id="PRO_0000247670"
SQ   SEQUENCE   171 AA;  18951 MW;  10617F0F28536A13 CRC64;
     MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG EQVVSGNADL
     GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN ANVIGFGGRI IGELLMCDII
     DAFINAEYKP TEENKKLIAK IKHLETSNAD QADPHFFDEF LEKWDRGEYH D