ID   LACB_STAAE              Reviewed;         171 AA.
AC   A6QJ38;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN   Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556}; OrderedLocusNames=NWMN_2098;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01556};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01556}.
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DR   EMBL; AP009351; BAF68370.1; -; Genomic_DNA.
DR   RefSeq; WP_000684746.1; NC_009641.1.
DR   AlphaFoldDB; A6QJ38; -.
DR   SMR; A6QJ38; -.
DR   EnsemblBacteria; BAF68370; BAF68370; NWMN_2098.
DR   KEGG; sae:NWMN_2098; -.
DR   HOGENOM; CLU_091396_2_0_9; -.
DR   OMA; ETHHANQ; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01556; LacB; 1.
DR   InterPro; IPR004784; LacB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01119; lacB; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..171
FT                   /note="Galactose-6-phosphate isomerase subunit LacB"
FT                   /id="PRO_1000073579"
SQ   SEQUENCE   171 AA;  18951 MW;  10617F0F28536A13 CRC64;
     MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG EQVVSGNADL
     GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN ANVIGFGGRI IGELLMCDII
     DAFINAEYKP TEENKKLIAK IKHLETSNAD QADPHFFDEF LEKWDRGEYH D