ID   LACB_STAAR              Reviewed;         171 AA.
AC   Q6GEN5;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN   Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556}; OrderedLocusNames=SAR2285;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01556};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01556}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01556}.
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DR   EMBL; BX571856; CAG41263.1; -; Genomic_DNA.
DR   RefSeq; WP_000684746.1; NC_002952.2.
DR   AlphaFoldDB; Q6GEN5; -.
DR   SMR; Q6GEN5; -.
DR   KEGG; sar:SAR2285; -.
DR   HOGENOM; CLU_091396_2_0_9; -.
DR   OMA; ETHHANQ; -.
DR   UniPathway; UPA00702; UER00714.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   HAMAP; MF_01556; LacB; 1.
DR   InterPro; IPR004784; LacB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   PANTHER; PTHR30345; PTHR30345; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR01119; lacB; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..171
FT                   /note="Galactose-6-phosphate isomerase subunit LacB"
FT                   /id="PRO_0000208138"
SQ   SEQUENCE   171 AA;  18951 MW;  10617F0F28536A13 CRC64;
     MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG EQVVSGNADL
     GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN ANVIGFGGRI IGELLMCDII
     DAFINAEYKP TEENKKLIAK IKHLETSNAD QADPHFFDEF LEKWDRGEYH D