LACB_STRPC
ID LACB_STRPC Reviewed; 171 AA.
AC Q1JJZ6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556};
GN OrderedLocusNames=MGAS9429_Spy1640;
OS Streptococcus pyogenes serotype M12 (strain MGAS9429).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=370551;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS9429;
RX PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA Musser J.M.;
RT "Molecular genetic anatomy of inter- and intraserotype variation in the
RT human bacterial pathogen group A Streptococcus.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01556}.
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DR EMBL; CP000259; ABF32827.1; -; Genomic_DNA.
DR RefSeq; WP_002988082.1; NC_008021.1.
DR AlphaFoldDB; Q1JJZ6; -.
DR SMR; Q1JJZ6; -.
DR EnsemblBacteria; ABF32827; ABF32827; MGAS9429_Spy1640.
DR KEGG; spk:MGAS9429_Spy1640; -.
DR HOGENOM; CLU_091396_2_0_9; -.
DR OMA; CCWTGTG; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000002433; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; -; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR PANTHER; PTHR30345; PTHR30345; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; SSF89623; 1.
DR TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism.
FT CHAIN 1..171
FT /note="Galactose-6-phosphate isomerase subunit LacB"
FT /id="PRO_1000068930"
SQ SEQUENCE 171 AA; 18893 MW; 3253828AA1A30238 CRC64;
MKIAVGCDHI VTYEKIAVVD YLKSQGHKVI DCGTYDNVRT HYPIFGKKVG EAVASGEAEL
GVVICGTGVG ITNAVNKVPG IRSALVRDMT SAIYSKEELN ANVIGFGGKI IGGLLMNDII
DAFLAAEYKP TEENKKWIEK MDSLQHASQD QNNPHFFDEF LEKWDRGEYH D