ID   ARCC_PSEAE              Reviewed;         310 AA.
AC   P13982;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
GN   Name=arcC; OrderedLocusNames=PA5173;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=2537202; DOI=10.1111/j.1432-1033.1989.tb14520.x;
RA   Baur H., Luethi E., Stalon V., Mercenier A., Haas D.;
RT   "Sequence analysis and expression of the arginine-deiminase and carbamate-
RT   kinase genes of Pseudomonas aeruginosa.";
RL   Eur. J. Biochem. 179:53-60(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- ACTIVITY REGULATION: Inhibited by ATP.
CC   -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC       degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; X14693; CAA32823.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG08558.1; -; Genomic_DNA.
DR   PIR; S02137; S02137.
DR   RefSeq; NP_253860.1; NC_002516.2.
DR   RefSeq; WP_003100033.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P13982; -.
DR   SMR; P13982; -.
DR   STRING; 287.DR97_2541; -.
DR   PaxDb; P13982; -.
DR   PRIDE; P13982; -.
DR   DNASU; 881793; -.
DR   EnsemblBacteria; AAG08558; AAG08558; PA5173.
DR   GeneID; 881793; -.
DR   KEGG; pae:PA5173; -.
DR   PATRIC; fig|208964.12.peg.5421; -.
DR   PseudoCAP; PA5173; -.
DR   HOGENOM; CLU_076278_0_1_6; -.
DR   InParanoid; P13982; -.
DR   OMA; QPMDVAG; -.
DR   PhylomeDB; P13982; -.
DR   BioCyc; PAER208964:G1FZ6-5290-MON; -.
DR   UniPathway; UPA00996; UER00366.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IMP:PseudoCAP.
DR   GO; GO:0019546; P:arginine deiminase pathway; IMP:PseudoCAP.
DR   GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..310
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185129"
SQ   SEQUENCE   310 AA;  33080 MW;  D5CA01AB4EA8F56C CRC64;
     MRIVVALGGN ALLRRGEPMT ADNQRENVRI AAEQIAKVAP GNELVIAHGN GPQVGLLALQ
     GAAYDKVSPY PLDVLGAETE GMIGYMIEQE MGNLLPFEVP FATILTQVEV DGKDPAFQNP
     TKPIGPVYSR EEAERLAAEK GWSIAPDGDK FRRVVPSPRP KRIFEIRPVK WLLEKGTIVI
     CAGGGGIPTM YDEAGKKLSG VEAVIDKDLC SSLLAQELVA DILIIATDVD AAYVDWGKPT
     QKAIAQAHPD ELERLGFAAG SMGPKVQAAI EFARATGKDA VIGSLADIVA ITEGKAGTRV
     STRKAGIEYR