LACC1_STRA3
ID LACC1_STRA3 Reviewed; 309 AA.
AC Q8E4R7;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Tagatose-6-phosphate kinase 1 {ECO:0000255|HAMAP-Rule:MF_01557};
DE EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE AltName: Full=Phosphotagatokinase 1 {ECO:0000255|HAMAP-Rule:MF_01557};
GN Name=lacC1 {ECO:0000255|HAMAP-Rule:MF_01557}; OrderedLocusNames=gbs1334;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01557};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR EMBL; AL766850; CAD46993.1; -; Genomic_DNA.
DR RefSeq; WP_000604309.1; NC_004368.1.
DR AlphaFoldDB; Q8E4R7; -.
DR SMR; Q8E4R7; -.
DR STRING; 211110.gbs1334; -.
DR EnsemblBacteria; CAD46993; CAD46993; CAD46993.
DR KEGG; san:gbs1334; -.
DR eggNOG; COG1105; Bacteria.
DR HOGENOM; CLU_050013_5_0_9; -.
DR OMA; GHVNMAH; -.
DR UniPathway; UPA00704; UER00715.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01164; FruK_PfkB_like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR HAMAP; MF_01557; LacC; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR005926; LacC.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR Pfam; PF00294; PfkB; 1.
DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR SUPFAM; SSF53613; SSF53613; 1.
DR TIGRFAMs; TIGR03168; 1-PFK; 1.
DR TIGRFAMs; TIGR01231; lacC; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding; Transferase.
FT CHAIN 1..309
FT /note="Tagatose-6-phosphate kinase 1"
FT /id="PRO_0000203927"
SQ SEQUENCE 309 AA; 33254 MW; 8079E5B82B6E559C CRC64;
MILTVTMNPS IDISYPLDVF KMDTVNRVAE VSKTAGGKGL NVTRVLAEIG DNVAATGLIG
GTNGHFLLQH LPQNIQAFFY EIAGDTRNCI AILHEGQQTE ILEAGPTIAA EEVNGFLHHY
RSLMGATDVV AISGSLPAGL PTEFYVQLVE IAHQFGNKVV LDCSGVALQA ALGSPVKPTA
IKPNNEELSQ LLGREVSKDL NELKEVLSEP LFEGIEWIIV SLGADGAFAK HWDTFYKVDI
PKIEVVNPVG SGDSTVAGIS SALSHQVDDY SLLKKANVLG MLNAQEKMTG HVNVSKYDNL
YNQITVKEV
