ID   LACC_LACLL              Reviewed;         310 AA.
AC   P23391;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Tagatose-6-phosphate kinase {ECO:0000255|HAMAP-Rule:MF_01557};
DE            EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE   AltName: Full=Phosphotagatokinase {ECO:0000255|HAMAP-Rule:MF_01557};
GN   Name=lacC {ECO:0000255|HAMAP-Rule:MF_01557};
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG   Plasmid pLP712.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, OPERON STRUCTURE, AND
RP   INDUCTION.
RC   STRAIN=MG1820;
RX   PubMed=1901863; DOI=10.1016/s0021-9258(20)89626-4;
RA   van Rooijen R.J., van Schalkwijk S., de Vos W.M.;
RT   "Molecular cloning, characterization, and nucleotide sequence of the
RT   tagatose 6-phosphate pathway gene cluster of the lactose operon of
RT   Lactococcus lactis.";
RL   J. Biol. Chem. 266:7176-7181(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC         1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC         ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01557};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC   -!- INDUCTION: By lactose. The operon consists of lacABCDFEGX.
CC       {ECO:0000269|PubMed:1901863}.
CC   -!- MISCELLANEOUS: This gene was sequenced from pMG820, a laboratory-
CC       derived deletion of the naturally occurring plasmid pLP712.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR   EMBL; M60447; AAA25179.1; -; Genomic_DNA.
DR   EMBL; M65190; AAA25170.1; -; Genomic_DNA.
DR   PIR; C39778; C39778.
DR   RefSeq; WP_002290553.1; NZ_WJUU01000033.1.
DR   RefSeq; YP_004761518.1; NC_015862.1.
DR   RefSeq; YP_005863084.1; NC_017478.1.
DR   AlphaFoldDB; P23391; -.
DR   SMR; P23391; -.
DR   BRENDA; 2.7.1.144; 2864.
DR   UniPathway; UPA00704; UER00715.
DR   PRO; PR:P23391; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01164; FruK_PfkB_like; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_01557; LacC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR005926; LacC.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR   Pfam; PF00294; PfkB; 1.
DR   PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR03168; 1-PFK; 1.
DR   TIGRFAMs; TIGR01231; lacC; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding; Plasmid;
KW   Transferase.
FT   CHAIN           1..310
FT                   /note="Tagatose-6-phosphate kinase"
FT                   /id="PRO_0000203915"
SQ   SEQUENCE   310 AA;  33250 MW;  7A3C3CB2701A32E5 CRC64;
     MILTVTLNPS VDISYPLETL KIDTVNRVKD VSKTAGGKGL NVTRVLYESG DKVTATGFLG
     GKIGEFIESE LEQSPVSPAF YKISGNTRNC IAILHEGNQT EILEQGPTIS HEEAEGFLDH
     YSNLIKQSEV VTISGSLPSG LPNDYYEKLI QLASDEGVAV VLDCSGAPLE TVLKSSAKPT
     AIKPNNEELS QLLGKEVTKD IEELKDVLKE SLFSGIEWIV VSLGRNGAFA KHGDVFYKVD
     IPDIPVVNPV GSGDSTVAGI ASALNSKKSD ADLLKHAMTL GMLNAQETMT GHVNMTNYET
     LNSQIGVKEV