LACC_STAES
ID LACC_STAES Reviewed; 310 AA.
AC Q8CRJ4;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Tagatose-6-phosphate kinase {ECO:0000255|HAMAP-Rule:MF_01557};
DE EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE AltName: Full=Phosphotagatokinase {ECO:0000255|HAMAP-Rule:MF_01557};
GN Name=lacC {ECO:0000255|HAMAP-Rule:MF_01557}; OrderedLocusNames=SE_1785;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01557};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR EMBL; AE015929; AAO05426.1; -; Genomic_DNA.
DR RefSeq; NP_765340.1; NC_004461.1.
DR RefSeq; WP_002468897.1; NZ_WBME01000007.1.
DR AlphaFoldDB; Q8CRJ4; -.
DR SMR; Q8CRJ4; -.
DR STRING; 176280.SE_1785; -.
DR EnsemblBacteria; AAO05426; AAO05426; SE_1785.
DR KEGG; sep:SE_1785; -.
DR PATRIC; fig|176280.10.peg.1742; -.
DR eggNOG; COG1105; Bacteria.
DR HOGENOM; CLU_050013_5_0_9; -.
DR OMA; QLNEPGP; -.
DR UniPathway; UPA00704; UER00715.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01164; FruK_PfkB_like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR HAMAP; MF_01557; LacC; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR005926; LacC.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR Pfam; PF00294; PfkB; 1.
DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR SUPFAM; SSF53613; SSF53613; 1.
DR TIGRFAMs; TIGR03168; 1-PFK; 1.
DR TIGRFAMs; TIGR01231; lacC; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding; Transferase.
FT CHAIN 1..310
FT /note="Tagatose-6-phosphate kinase"
FT /id="PRO_0000203923"
SQ SEQUENCE 310 AA; 34229 MW; 0F62175491B56676 CRC64;
MILTLTLNPS VDISYPLDQF NLDTVNRVSQ TSKTAGGKGL NVTRVLSEFG EDVIASGFLG
GALGQYIEEQ IETTRIKQAF FKIKGETRNC IAILHEGQQT EILEKGPTIE LKESEEFKSH
LLKLFKETDV AVMSGSLPKG LNTDYYTDIV RLAKEQGILT ILDSSGQSLE EVLISNEKPT
VIKPNIDELS QLLNYKVTND IKELKAAVSQ PIFNDIEWII VSLGSEGAFA KHNQKFYKVN
IPNIKVVNPV GSGDSTVAGI ASGLIHQQTD EELLKKANAF GMLNAMEQQT GHINTDKFDE
IFKQIEVIEV
