ID   LACC_STRPJ              Reviewed;         309 AA.
AC   B8ZQ64;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Tagatose-6-phosphate kinase {ECO:0000255|HAMAP-Rule:MF_01557};
DE            EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE   AltName: Full=Phosphotagatokinase {ECO:0000255|HAMAP-Rule:MF_01557};
GN   Name=lacC {ECO:0000255|HAMAP-Rule:MF_01557}; OrderedLocusNames=SPN23F10900;
OS   Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=561276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700669 / Spain 23F-1;
RX   PubMed=19114491; DOI=10.1128/jb.01343-08;
RA   Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C.,
RA   Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D.,
RA   Mitchell T.J.;
RT   "Role of conjugative elements in the evolution of the multidrug-resistant
RT   pandemic clone Streptococcus pneumoniae Spain23F ST81.";
RL   J. Bacteriol. 191:1480-1489(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC         1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC         ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01557};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR   EMBL; FM211187; CAR68903.1; -; Genomic_DNA.
DR   RefSeq; WP_000604274.1; NC_011900.1.
DR   AlphaFoldDB; B8ZQ64; -.
DR   SMR; B8ZQ64; -.
DR   KEGG; sne:SPN23F10900; -.
DR   HOGENOM; CLU_050013_5_0_9; -.
DR   OMA; QLNEPGP; -.
DR   UniPathway; UPA00704; UER00715.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01164; FruK_PfkB_like; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_01557; LacC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR005926; LacC.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR   Pfam; PF00294; PfkB; 1.
DR   PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR03168; 1-PFK; 1.
DR   TIGRFAMs; TIGR01231; lacC; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding; Transferase.
FT   CHAIN           1..309
FT                   /note="Tagatose-6-phosphate kinase"
FT                   /id="PRO_1000185409"
SQ   SEQUENCE   309 AA;  33416 MW;  6CA201CE0C2C8A4D CRC64;
     MILTVTMNPS IDISYPLDEL KIDTVNRVVD VTKTAGGKGL NVTRVLSEFG DSVLATGLVG
     GKLGEFLVEH IDNQVKKDFF SIQGETRNCI AILHGDNQTE VLEKGPEVLE QEGQDFLEHF
     KKLLESVEVV AISGSLPAGL PVDYYASLVE LANQAGKPVV LDCSGAALQA VLESPHKPTV
     IKPNNEELSQ LLGREVSEDL DELKEVLQEP LFAGIEWIIV SLGANGTFAK HGDTFYKVDI
     PRIQVVNPVG SGDSTVAGIS SGLLHKESDA ELLIKANVLG MLNTQEKMTG HVNMANYQAL
     YDQLIVKEV