ID   LACC_STRPN              Reviewed;         309 AA.
AC   Q97QL2;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Tagatose-6-phosphate kinase {ECO:0000255|HAMAP-Rule:MF_01557};
DE            EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE   AltName: Full=Phosphotagatokinase {ECO:0000255|HAMAP-Rule:MF_01557};
GN   Name=lacC {ECO:0000255|HAMAP-Rule:MF_01557}; OrderedLocusNames=SP_1191;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC         1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC         ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01557};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR   EMBL; AE005672; AAK75300.1; -; Genomic_DNA.
DR   PIR; C95138; C95138.
DR   RefSeq; WP_000604264.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97QL2; -.
DR   SMR; Q97QL2; -.
DR   STRING; 170187.SP_1191; -.
DR   EnsemblBacteria; AAK75300; AAK75300; SP_1191.
DR   KEGG; spn:SP_1191; -.
DR   eggNOG; COG1105; Bacteria.
DR   OMA; QLNEPGP; -.
DR   PhylomeDB; Q97QL2; -.
DR   BioCyc; SPNE170187:G1FZB-1208-MON; -.
DR   UniPathway; UPA00704; UER00715.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01164; FruK_PfkB_like; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_01557; LacC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR005926; LacC.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR   Pfam; PF00294; PfkB; 1.
DR   PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR03168; 1-PFK; 1.
DR   TIGRFAMs; TIGR01231; lacC; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding; Transferase.
FT   CHAIN           1..309
FT                   /note="Tagatose-6-phosphate kinase"
FT                   /id="PRO_0000203931"
SQ   SEQUENCE   309 AA;  33440 MW;  B96893836026237D CRC64;
     MILTVTMNPS IDISYPLDEL KIDTVNRVVD VTKTAGGKGL NVTRVLSEFG DSVLATGLVG
     GKLGEFLVEH IDNQVKKDFF SIKGETRNCI AILHGDNQTE VLEKGPEVLE QEGQEFLEHF
     KKLLESVEVV AISGSLPAGL PVDYYASLVE LANQAGKHVV LDCSGAALQA VLESPHKPTV
     IKPNNEELSQ LLGREVSEDL DELKEVLQEP LFAGIEWIIV SLGANGTFAK HGDTFYKVDI
     PRIQVVNPVG SGDSTVAGIS SGLLHKESDA ELLIKANVLG MLNAQEKMTG HVNMANYQAL
     YDQLIVKEV