ID   LACC_STRSV              Reviewed;         309 AA.
AC   A3CPH5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Tagatose-6-phosphate kinase {ECO:0000255|HAMAP-Rule:MF_01557};
DE            EC=2.7.1.144 {ECO:0000255|HAMAP-Rule:MF_01557};
DE   AltName: Full=Phosphotagatokinase {ECO:0000255|HAMAP-Rule:MF_01557};
GN   Name=lacC {ECO:0000255|HAMAP-Rule:MF_01557}; OrderedLocusNames=SSA_1697;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose
CC         1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695,
CC         ChEBI:CHEBI:456216; EC=2.7.1.144; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01557};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01557}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01557}.
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DR   EMBL; CP000387; ABN45080.1; -; Genomic_DNA.
DR   RefSeq; WP_011837290.1; NC_009009.1.
DR   RefSeq; YP_001035630.1; NC_009009.1.
DR   AlphaFoldDB; A3CPH5; -.
DR   SMR; A3CPH5; -.
DR   STRING; 388919.SSA_1697; -.
DR   EnsemblBacteria; ABN45080; ABN45080; SSA_1697.
DR   KEGG; ssa:SSA_1697; -.
DR   PATRIC; fig|388919.9.peg.1609; -.
DR   eggNOG; COG1105; Bacteria.
DR   HOGENOM; CLU_050013_5_0_9; -.
DR   OMA; GHVNMAH; -.
DR   OrthoDB; 1323781at2; -.
DR   UniPathway; UPA00704; UER00715.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01164; FruK_PfkB_like; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_01557; LacC; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR005926; LacC.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR   Pfam; PF00294; PfkB; 1.
DR   PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR03168; 1-PFK; 1.
DR   TIGRFAMs; TIGR01231; lacC; 1.
DR   PROSITE; PS00583; PFKB_KINASES_1; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Lactose metabolism; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..309
FT                   /note="Tagatose-6-phosphate kinase"
FT                   /id="PRO_1000068944"
SQ   SEQUENCE   309 AA;  33200 MW;  1014F09B0EF335B9 CRC64;
     MILTVTMNPS IDISYPLEEL KIDTVNRVSE VSKTAGGKGL NVTRVLAEIG DNVAATGLIG
     GTNGEFLLQN LNQAVRPLFY NISGDTRNCI AILHESKQTE ILEAGPTITV DEANGFLHHF
     KSLMESAEVV SISGSLPAGL PVEYYIQLVE IANQAGNKVV LDCSGAALEA VLKSDVKPTA
     IKPNNEELSQ LLGREVSKDL DELKAVLSEP LFDGIEWIIV SLGADGAFAK HWETFYKVDI
     PKIQVVNPVG SGDSTVAGIS SALSHQADDV SLLKKANVLG MLNAQEKMTG HVNVENYDDL
     YNQITVKEV