ID   LACD1_STRA3             Reviewed;         325 AA.
AC   Q8E347;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
DE            EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=Tagatose-bisphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
GN   Name=lacD1 {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=gbs1915;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00734}.
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DR   EMBL; AL766854; CAD47574.1; -; Genomic_DNA.
DR   RefSeq; WP_000524689.1; NC_004368.1.
DR   AlphaFoldDB; Q8E347; -.
DR   SMR; Q8E347; -.
DR   STRING; 211110.gbs1915; -.
DR   EnsemblBacteria; CAD47574; CAD47574; CAD47574.
DR   GeneID; 66886712; -.
DR   KEGG; san:gbs1915; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; HEKVIVE; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..325
FT                   /note="Tagatose 1,6-diphosphate aldolase 1"
FT                   /id="PRO_0000203954"
SQ   SEQUENCE   325 AA;  36443 MW;  9F730C3ADFD8E0BD CRC64;
     MGLTEQKQKH MEQLSDKNGI ISALAFDQRG ALKRLMAKYQ SEEPTVSQIE ALKVLVAEEL
     TPYASSMLLD PEYGLPATKV LDDNAGLLLA YEKTGYDTSS TKRLPDCLDI WSAKRIKEEG
     ADAVKFLLYY DVDSSDEVNE EKEAYIERIG SECVAEDIPF FLEILSYDEK ITDSSGIEYA
     KIKPRKVIEA MKVFSNPRFN IDVLKVEVPV NMDYVEGFAQ GETAYNKATA AAYFREQDQA
     TLLPYIFLSA GVPAQLFQET LVFAKEAGAK FNGVLCGRAT WAGSVKEYVE KGEAGARQWL
     RTIGFQNIDE LNKILQKTAT SWKER