ID   LACD1_STRMU             Reviewed;         325 AA.
AC   P26425;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 1;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1;
DE   AltName: Full=Tagatose-bisphosphate aldolase 1;
GN   Name=lacD1; Synonyms=lacD; OrderedLocusNames=SMU_1493;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1400164; DOI=10.1128/jb.174.19.6159-6170.1992;
RA   Rosey E.L., Stewart G.C.;
RT   "Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and
RT   lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and
RT   sugar-specific phosphotransferase system components of the lactose operon
RT   of Streptococcus mutans.";
RL   J. Bacteriol. 174:6159-6170(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; M80797; AAA26907.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59147.1; -; Genomic_DNA.
DR   PIR; F43258; F43258.
DR   RefSeq; NP_721841.1; NC_004350.2.
DR   RefSeq; WP_002277661.1; NC_004350.2.
DR   AlphaFoldDB; P26425; -.
DR   SMR; P26425; -.
DR   STRING; 210007.SMU_1493; -.
DR   PRIDE; P26425; -.
DR   EnsemblBacteria; AAN59147; AAN59147; SMU_1493.
DR   KEGG; smu:SMU_1493; -.
DR   PATRIC; fig|210007.7.peg.1329; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; VKHQTEE; -.
DR   PhylomeDB; P26425; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Tagatose 1,6-diphosphate aldolase 1"
FT                   /id="PRO_0000203957"
FT   CONFLICT        323
FT                   /note="K -> E (in Ref. 1; AAA26907)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  36490 MW;  5B1534D6CD6E899A CRC64;
     MTLTQEKRSY MEKLSDENGI ISALAFDQRG ALKRLMAQYQ TQEPTIAQME ELKVLVAEEL
     TPYASSMLLD PEYGLPAAKH LDKNAGLLLA YEKTGYDTTS TKRLPDCLVE WSAKRLKKQG
     ADAVKFLLYY DVDGDEEVNQ QKQAYIERIG SECKAEDIPF FLEILAYDET ITDAASVEYA
     KVKPHKVLDA MKVFSDERFG IDVLKVEVPV NMKYVEGFGD GPIVHTQDQA ANFFKQQDQA
     TPLPYIYLSA GVSAKLFQDT LVFAKESGAN FNGVLCGRAT WAGSVKDYIE KGEAAARQWL
     RTEGFKNIDE LNKVLKATAT SWKER