ID   LACD1_STRP3             Reviewed;         325 AA.
AC   P0DC14; Q879I5; Q8K654;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 1;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1;
DE   AltName: Full=Tagatose-bisphosphate aldolase 1;
GN   Name=lacD1; Synonyms=lacD.1; OrderedLocusNames=SpyM3_1482;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; AE014074; AAM80089.1; -; Genomic_DNA.
DR   RefSeq; WP_011054918.1; NC_004070.1.
DR   AlphaFoldDB; P0DC14; -.
DR   SMR; P0DC14; -.
DR   EnsemblBacteria; AAM80089; AAM80089; SpyM3_1482.
DR   KEGG; spg:SpyM3_1482; -.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; VAWLETT; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..325
FT                   /note="Tagatose 1,6-diphosphate aldolase 1"
FT                   /id="PRO_0000203962"
SQ   SEQUENCE   325 AA;  36011 MW;  A182F0041D52AF83 CRC64;
     MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET LKVLVSEELT
     PYASSILLDP EYGLLATKVK ANQTGLLLVY EKTGYDATTT SRLPDCLVEW SVKRLKAAGA
     DAIKFLLYYD VDGDEQINLQ KQAYIERIGS ECTAEDIPFF LELLSYDERI SDNNSAAYAK
     LKPHKVNGAM SVFSDKRFGV DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS
     HLPYIYLSAG VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
     TEGFQNIDEL NRVLEETASP WTEKI