LACD1_STRP6
ID LACD1_STRP6 Reviewed; 325 AA.
AC Q5XAI4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD1 {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=M6_Spy1444;
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394;
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; CP000003; AAT87579.1; -; Genomic_DNA.
DR RefSeq; WP_011106626.1; NC_006086.1.
DR AlphaFoldDB; Q5XAI4; -.
DR SMR; Q5XAI4; -.
DR EnsemblBacteria; AAT87579; AAT87579; M6_Spy1444.
DR KEGG; spa:M6_Spy1444; -.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; VAWLETT; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase.
FT CHAIN 1..325
FT /note="Tagatose 1,6-diphosphate aldolase 1"
FT /id="PRO_0000203963"
SQ SEQUENCE 325 AA; 35983 MW; FB342B69AF38F926 CRC64;
MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET LKVLVSEELT
PYASSILLDP EYGLLATKVK ANQTGLLLAY EKTGYDATTT SRLPDCLVEW SVKRLKAAGA
DAIKFLLYYD VDGDEQINLQ KQAYIERIGS ECTAEDIPFF LELLSYDERI SDNNSAAYAK
LKPHKVNGAM SVFSDKRFGV DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS
HLPYIYLSAG VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
TEGFQNIDEL NRVLEETASP WTEKI