ID   LACD1_STRP8             Reviewed;         325 AA.
AC   P63704; Q99YH3;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 1;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1;
DE   AltName: Full=Tagatose-bisphosphate aldolase 1;
GN   Name=lacD1; Synonyms=lacD.1; OrderedLocusNames=spyM18_1714;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE009949; AAL98245.1; -; Genomic_DNA.
DR   RefSeq; WP_002983521.1; NC_003485.1.
DR   AlphaFoldDB; P63704; -.
DR   SMR; P63704; -.
DR   GeneID; 57853089; -.
DR   KEGG; spm:spyM18_1714; -.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; VAWLETT; -.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..325
FT                   /note="Tagatose 1,6-diphosphate aldolase 1"
FT                   /id="PRO_0000203964"
SQ   SEQUENCE   325 AA;  36011 MW;  7B3A1B69AF3C471E CRC64;
     MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET LKVLVSEELT
     PYASSILLDP EYGLLATKVR ANQTGLLLAY EKTGYDATTT SRLPDCLVEW SVKRLKAAGA
     DAIKFLLYYD VDGDEQINLQ KQAYIERIGS ECTAEDIPFF LELLSYDERI SDNNSAAYAK
     LKPHKVNGAM SVFSDKRFGV DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS
     HLPYIYLSAG VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
     TEGFQNIDEL NRVLEETASP WTEKI