ID   LACD1_STRPQ             Reviewed;         325 AA.
AC   P0DC15; Q879I5; Q8K654;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 1;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 1;
DE   AltName: Full=Tagatose-bisphosphate aldolase 1;
GN   Name=lacD1; Synonyms=lacD.1; OrderedLocusNames=SPs0385;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; BA000034; BAC63480.1; -; Genomic_DNA.
DR   RefSeq; WP_011106626.1; NC_004606.1.
DR   AlphaFoldDB; P0DC15; -.
DR   SMR; P0DC15; -.
DR   KEGG; sps:SPs0385; -.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; VAWLETT; -.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..325
FT                   /note="Tagatose 1,6-diphosphate aldolase 1"
FT                   /id="PRO_0000411395"
SQ   SEQUENCE   325 AA;  35983 MW;  FB342B69AF38F926 CRC64;
     MTITANKRHY LEKVSHQGII SALAFDQRGA LKQMMAAHQE GEATVTQIET LKVLVSEELT
     PYASSILLDP EYGLLATKVK ANQTGLLLAY EKTGYDATTT SRLPDCLVEW SVKRLKAAGA
     DAIKFLLYYD VDGDEQINLQ KQAYIERIGS ECTAEDIPFF LELLSYDERI SDNNSAAYAK
     LKPHKVNGAM SVFSDKRFGV DVLKVEVPVN MAYVEGFTEG EVHYSQAEAI KAFQDQEAAS
     HLPYIYLSAG VSAKLFQETL YFAAAAGAQF SGVLCGRATW AGSVPVYITK GEDEARKWLC
     TEGFQNIDEL NRVLEETASP WTEKI