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LACD2_ENTFA
ID   LACD2_ENTFA             Reviewed;         331 AA.
AC   Q833W8;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 2;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 2;
DE   AltName: Full=Tagatose-bisphosphate aldolase 2;
GN   Name=lacD2; Synonyms=lacD-2; OrderedLocusNames=EF_1807;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; AE016830; AAO81575.1; -; Genomic_DNA.
DR   RefSeq; NP_815505.1; NC_004668.1.
DR   RefSeq; WP_002357245.1; NZ_KE136528.1.
DR   AlphaFoldDB; Q833W8; -.
DR   SMR; Q833W8; -.
DR   STRING; 226185.EF_1807; -.
DR   EnsemblBacteria; AAO81575; AAO81575; EF_1807.
DR   GeneID; 60894096; -.
DR   KEGG; efa:EF1807; -.
DR   PATRIC; fig|226185.45.peg.1711; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; KDITRPS; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Tagatose 1,6-diphosphate aldolase 2"
FT                   /id="PRO_0000203939"
SQ   SEQUENCE   331 AA;  36625 MW;  3EF013AEE565F2FE CRC64;
     MLTLTAGKKA AMDRLSTQEG IISALAIDQR GALKKMIKAL DVEPTDAQIE TFKELVSKEL
     TPYASAILLD PEYGLPAAKA RDTEAGLLLA YEKTGYDATT PGRLPDLLAD WSVLRLKEEG
     ADAIKFLLYY DVDEDPEINH QKHVFIERLG SECAEEDLPF YLELVSYDAQ IADATSLEYA
     KVKPHKVNEM MKEFSKPQYK VDVLKVEVPV NMNFVEGFAP AETAYTKEEA ANYFLEQSQA
     TDLPFIFLSA GVSTELFQET LRFAKEAGST FNGVLCGRAT WKNGVKPFVE AGETAACDWL
     KTEGRENIES LNEVIAATAS SWHAKVQVNE G
 
 
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