ID   LACD2_STRA3             Reviewed;         326 AA.
AC   Q8E4R8;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 2;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 2;
DE   AltName: Full=Tagatose-bisphosphate aldolase 2;
GN   Name=lacD2; OrderedLocusNames=gbs1333;
OS   Streptococcus agalactiae serotype III (strain NEM316).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=211110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEM316;
RX   PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA   Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA   Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT   "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT   neonatal disease.";
RL   Mol. Microbiol. 45:1499-1513(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; AL766850; CAD46992.1; -; Genomic_DNA.
DR   RefSeq; WP_000244543.1; NC_004368.1.
DR   AlphaFoldDB; Q8E4R8; -.
DR   SMR; Q8E4R8; -.
DR   STRING; 211110.gbs1333; -.
DR   PRIDE; Q8E4R8; -.
DR   EnsemblBacteria; CAD46992; CAD46992; CAD46992.
DR   KEGG; san:gbs1333; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; KDYIEQG; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000000823; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..326
FT                   /note="Tagatose 1,6-diphosphate aldolase 2"
FT                   /id="PRO_0000203956"
SQ   SEQUENCE   326 AA;  36642 MW;  C878B08DA7FFA197 CRC64;
     MVLTEQKRKY MEKLSDENGI ISALAFDQRG ALKRLMAQYQ EAEPTVEQME DLKVLVAEEL
     TPYASSMLLD PEYGLPATKA LDKNAGLLLA YEKTGYDTSS TKRLPDCLDV WSAKRIKEQG
     SDAVKFLLYY DVDSSDELNQ QKQAYIERVG SECVAEDIPF FLEILAYDEK IADAGSAEYA
     KVKPRKVIEA MKVFSDSRFN IDVLKVEVPV NVKYVEGFGD GEVIHTRGEA AAFFKQQDEA
     TNLPYIYLSA GVAAKLFQET LIFAHESGAN FNGVLCGRAT WAGSVKEYIE QGEEAARQWL
     RTTGYQNIEE LNQVLKQTAT SWKERV