ID   LACD2_STRP6             Reviewed;         327 AA.
AC   Q5X9Y4;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 2 {ECO:0000255|HAMAP-Rule:MF_00734};
DE            EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 2 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=Tagatose-bisphosphate aldolase 2 {ECO:0000255|HAMAP-Rule:MF_00734};
GN   Name=lacD2 {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=M6_Spy1644;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00734}.
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DR   EMBL; CP000003; AAT87779.1; -; Genomic_DNA.
DR   RefSeq; WP_011184964.1; NC_006086.1.
DR   AlphaFoldDB; Q5X9Y4; -.
DR   SMR; Q5X9Y4; -.
DR   EnsemblBacteria; AAT87779; AAT87779; M6_Spy1644.
DR   KEGG; spa:M6_Spy1644; -.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; KDITRPS; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..327
FT                   /note="Tagatose 1,6-diphosphate aldolase 2"
FT                   /id="PRO_0000203967"
SQ   SEQUENCE   327 AA;  36605 MW;  58348D769D39DED0 CRC64;
     MTITLTENKR KSMEKLSIDG VISALAFDQR GALKRMMAQH QTKEPTVEQI EELKSLVSEE
     LTPFASSILL DPEYGLPASR VRSEEAGLLL AYEKTGYDAT TTSRLPDCLD VWSAKRIKEA
     GAEAVKFLLY YDIDGDQDVN EQKKAYIERI GSECRAEDIP FYLEILTYDE KIADNASPEF
     AKVKAHKVNE AMKVFSKERF GVDVLKVEVP VNMKFVEGFA DGEILFTKEE AAQAFRDQEA
     STDLPYIYLS AGVSAKLFQD TLVFAAESGA KFNGVLCGRA TWAGSVKVYI EEGPQAAREW
     LRTEGFKNID ELNKVLDKTA SPWTEKM