ID   LACD2_STRP8             Reviewed;         327 AA.
AC   P63706; Q99Y15;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase 2;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase 2;
DE   AltName: Full=Tagatose-bisphosphate aldolase 2;
GN   Name=lacD2; Synonyms=lacD.2; OrderedLocusNames=spyM18_1987;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; AE009949; AAL98473.1; -; Genomic_DNA.
DR   RefSeq; WP_002982755.1; NC_003485.1.
DR   AlphaFoldDB; P63706; -.
DR   SMR; P63706; -.
DR   KEGG; spm:spyM18_1987; -.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; KDITRPS; -.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase.
FT   CHAIN           1..327
FT                   /note="Tagatose 1,6-diphosphate aldolase 2"
FT                   /id="PRO_0000203968"
SQ   SEQUENCE   327 AA;  36577 MW;  4E179B441A90543E CRC64;
     MTITLTENKR KSMEKLSVDG VISALAFDQR GALKRMMAQH QTKEPTVEQI EELKSLVSEE
     LTPFASSILL DPEYGLPASR VRSEEAGLLL AYEKTGYDAT TTSRLPDCLD VWSAKRIKEA
     GAEAVKFLLY YDIDGDQDVN EQKKAYIERI GSECRAEDIP FYLEILTYDE KIADNASPEF
     AKVKAHKVNE AMKVFSKERF GVDVLKVEVP VNMKFVEGFA DGEVLFTKEE AAQAFRDQEA
     STDLPYIYLS AGVSAKLFQD TLVFAAESGA KFNGVLCGRA TWAGSVKVYI EEGPQAAREW
     LRTEGFKNID ELNKVLDKTA SPWTEKM