LACD_LISMC
ID LACD_LISMC Reviewed; 338 AA.
AC C1L056;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=Lm4b_00565;
OS Listeria monocytogenes serotype 4b (strain CLIP80459).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=568819;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP80459;
RX PubMed=22530965; DOI=10.1186/1471-2164-13-144;
RA Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B.,
RA Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A.,
RA Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P.,
RA Rusniok C., Buchrieser C., Goebel W., Chakraborty T.;
RT "Comparative genomics and transcriptomics of lineages I, II, and III
RT strains of Listeria monocytogenes.";
RL BMC Genomics 13:144-144(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; FM242711; CAS04333.1; -; Genomic_DNA.
DR RefSeq; WP_003725443.1; NC_012488.1.
DR AlphaFoldDB; C1L056; -.
DR SMR; C1L056; -.
DR KEGG; lmc:Lm4b_00565; -.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; HEKVIVE; -.
DR BioCyc; LMON568819:LM4B_RS02795-MON; -.
DR UniPathway; UPA00704; UER00716.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase.
FT CHAIN 1..338
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_1000212740"
SQ SEQUENCE 338 AA; 37698 MW; FC260F0DD337B53D CRC64;
MVQITKGKFD GLQRLSNEKG VIAALAIDQR GSLKKMIQQA KGTENKKDVE DFKQLVSEEL
TPYASAILLD LEYGTPAIKA RHEGSGLLTS YEKTGYDATT PGKLPDLIED LSALRIKENG
GDAVKILVYY DPDEPAEINE IKYAFLERIG AECRAVDIPF FLEPITYDAT VTDSGSLEYA
KLKPAKVKAS IKEFSKPRYG VDVLKLEVPV NFKYVEGFAE GEVAYTQDEA ARHFEECSDL
SPLPFIYLSA GVTSEMFHKT IQFANQHNVQ YSGVLCGRAT WADGIEVYGK QGDDALREWL
RTQGKENITS LDKLLDEGAV PWWTKYGSFE DVHVVEKQ