ID   LACD_LISMO              Reviewed;         338 AA.
AC   Q8Y9I9;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE            EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN   Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=lmo0539;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00734}.
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DR   EMBL; AL591975; CAC98618.1; -; Genomic_DNA.
DR   PIR; AD1142; AD1142.
DR   RefSeq; NP_464067.1; NC_003210.1.
DR   RefSeq; WP_003721333.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y9I9; -.
DR   SMR; Q8Y9I9; -.
DR   STRING; 169963.lmo0539; -.
DR   PaxDb; Q8Y9I9; -.
DR   EnsemblBacteria; CAC98618; CAC98618; CAC98618.
DR   GeneID; 985316; -.
DR   KEGG; lmo:lmo0539; -.
DR   PATRIC; fig|169963.11.peg.558; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; HEKVIVE; -.
DR   PhylomeDB; Q8Y9I9; -.
DR   BioCyc; LMON169963:LMO0539-MON; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0061595; F:6-deoxy-6-sulfofructose-1-phosphate aldolase activity; IBA:GO_Central.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902777; P:6-sulfoquinovose(1-) catabolic process; IBA:GO_Central.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase; Reference proteome.
FT   CHAIN           1..338
FT                   /note="Tagatose 1,6-diphosphate aldolase"
FT                   /id="PRO_0000203943"
SQ   SEQUENCE   338 AA;  37684 MW;  62A3647DB8D9303D CRC64;
     MVQITKGKFD GLQRLSNDKG VIAALAIDQR GSLKKMIQQA KGTENKKDVE DFKQLVSEEL
     TPYASAILLD LEYGTPAIKA RHEGSGLLTS YEKTGYDATT PGKLPDLIED LSALRIKENG
     GDAVKILVYY DPDEPAEINE IKYAFLERIG AECRAVDIPF FLEPITYDAT VTDSGSLEYA
     KLKPAKVKAS IKEFSKPRYG VDVLKLEVPV NFKYVEGFAE GEVAYTQDEA ARHFEECSDL
     SPLPFIYLSA GVTSEMFHKT IQFANQHNVQ YSGVLCGRAT WADGIEVYGK QGDDALREWL
     RTQGKENITS LDKLLDEGAV PWWTKYGSFE DVHVVEKQ