ID   LACD_STAA8              Reviewed;         326 AA.
AC   P0A011; P11100; Q2G2R3;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase;
DE   AltName: Full=Tagatose-bisphosphate aldolase;
GN   Name=lacD; OrderedLocusNames=SAOUHSC_02452;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2543958; DOI=10.1093/nar/17.10.3980;
RA   Rosey E.L., Stewart G.C.;
RT   "The nucleotide sequence of the lacC and lacD genes of Staphylococcus
RT   aureus.";
RL   Nucleic Acids Res. 17:3980-3980(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=1655695; DOI=10.1128/jb.173.19.5992-5998.1991;
RA   Rosey E.L., Oskouian B., Stewart G.C.;
RT   "Lactose metabolism by Staphylococcus aureus: characterization of lacABCD,
RT   the structural genes of the tagatose 6-phosphate pathway.";
RL   J. Bacteriol. 173:5992-5998(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR   EMBL; X14827; CAA32936.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD31472.1; -; Genomic_DNA.
DR   PIR; S04359; S04359.
DR   RefSeq; WP_000047009.1; NZ_LS483365.1.
DR   RefSeq; YP_500919.1; NC_007795.1.
DR   AlphaFoldDB; P0A011; -.
DR   SMR; P0A011; -.
DR   STRING; 1280.SAXN108_2445; -.
DR   EnsemblBacteria; ABD31472; ABD31472; SAOUHSC_02452.
DR   GeneID; 3919015; -.
DR   KEGG; sao:SAOUHSC_02452; -.
DR   PATRIC; fig|93061.5.peg.2211; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; KDITRPS; -.
DR   UniPathway; UPA00704; UER00716.
DR   PRO; PR:P0A011; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0061595; F:6-deoxy-6-sulfofructose-1-phosphate aldolase activity; IBA:GO_Central.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902777; P:6-sulfoquinovose(1-) catabolic process; IBA:GO_Central.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   1: Evidence at protein level;
KW   Lactose metabolism; Lyase; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Tagatose 1,6-diphosphate aldolase"
FT                   /id="PRO_0000203949"
SQ   SEQUENCE   326 AA;  36595 MW;  20766B1B841372C1 CRC64;
     MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE QLKVLVAEEL
     TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG
     ANAVKFLLYY DVDDAEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNGSVEFA
     KVKPRKVNEA MKLFSEPRFN VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA
     THLPYIYLSA GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL
     RTTGFKNIDD LNKVLKDTAT SWKQRK