LACD_STAAM
ID LACD_STAAM Reviewed; 326 AA.
AC P0A009; P11100;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase;
DE EC=4.1.2.40;
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase;
DE AltName: Full=Tagatose-bisphosphate aldolase;
GN Name=lacD; OrderedLocusNames=SAV2192;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000305}.
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DR EMBL; BA000017; BAB58354.1; -; Genomic_DNA.
DR RefSeq; WP_000047009.1; NC_002758.2.
DR PDB; 3KAO; X-ray; 1.90 A; A=1-326.
DR PDBsum; 3KAO; -.
DR AlphaFoldDB; P0A009; -.
DR SMR; P0A009; -.
DR World-2DPAGE; 0002:P0A009; -.
DR PaxDb; P0A009; -.
DR EnsemblBacteria; BAB58354; BAB58354; SAV2192.
DR KEGG; sav:SAV2192; -.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; KDITRPS; -.
DR PhylomeDB; P0A009; -.
DR BioCyc; SAUR158878:SAV_RS11990-MON; -.
DR UniPathway; UPA00704; UER00716.
DR EvolutionaryTrace; P0A009; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Lactose metabolism; Lyase.
FT CHAIN 1..326
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_0000203945"
FT HELIX 5..14
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 21..26
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 30..37
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 46..60
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 65..69
FT /evidence="ECO:0007829|PDB:3KAO"
FT TURN 71..73
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 75..79
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 86..90
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 113..118
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 122..130
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 136..156
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 160..166
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 177..194
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 197..199
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 202..206
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 212..214
FT /evidence="ECO:0007829|PDB:3KAO"
FT TURN 216..218
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 227..239
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 245..248
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 254..267
FT /evidence="ECO:0007829|PDB:3KAO"
FT STRAND 273..276
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 278..281
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 284..290
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 293..301
FT /evidence="ECO:0007829|PDB:3KAO"
FT HELIX 303..318
FT /evidence="ECO:0007829|PDB:3KAO"
SQ SEQUENCE 326 AA; 36595 MW; 20766B1B841372C1 CRC64;
MSKSNQKIAS IEQLSNNEGI ISALAFDQRG ALKRMMAKHQ TEEPTVAQIE QLKVLVAEEL
TQYASSILLD PEYGLPASDA RNKDCGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG
ANAVKFLLYY DVDDAEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNGSVEFA
KVKPRKVNEA MKLFSEPRFN VDVLKVEVPV NMKYVEGFAE GEVVYTKEEA AQHFKDQDAA
THLPYIYLSA GVSAELFQET LKFAHEAGAK FNGVLCGRAT WSGAVQVYIE QGEDAAREWL
RTTGFKNIDD LNKVLKDTAT SWKQRK
