LACD_STAEQ
ID LACD_STAEQ Reviewed; 325 AA.
AC Q5HM38;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=SERP1792;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; CP000029; AAW55177.1; -; Genomic_DNA.
DR RefSeq; WP_002456993.1; NC_002976.3.
DR AlphaFoldDB; Q5HM38; -.
DR SMR; Q5HM38; -.
DR STRING; 176279.SERP1792; -.
DR PRIDE; Q5HM38; -.
DR EnsemblBacteria; AAW55177; AAW55177; SERP1792.
DR KEGG; ser:SERP1792; -.
DR eggNOG; COG3684; Bacteria.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; KDITRPS; -.
DR OrthoDB; 1560751at2; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase; Reference proteome.
FT CHAIN 1..325
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_0000203952"
SQ SEQUENCE 325 AA; 36552 MW; DBCE4AF33741F2C6 CRC64;
MTKSQQKVSS IEKLSNQEGI ISALAFDQRG ALKRMMAEHQ SETPTVEQIE QLKVLVSEEL
TQYASSILLD PEYGLPASDA RNNDCGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG
ANAVKFLLYY DVDDTEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNKSAEFA
KVKPRKVNEA MKLFSEDRFN VDVLKVEVPV NMNFVEGFSE GEVVYTKEEA AQHFRDQDAA
THLPYIYLSA GVSAELFQDT LKFAHDSGAQ FNGVLCGRAT WSGAVKVYIE EGEQAAREWL
RTVGFKNIDD LNTVLKTTAT SWKNK
