LACD_STAES
ID LACD_STAES Reviewed; 325 AA.
AC Q8CNF5;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=SE_1784;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; AE015929; AAO05425.1; -; Genomic_DNA.
DR RefSeq; NP_765339.1; NC_004461.1.
DR RefSeq; WP_011082764.1; NZ_WBME01000007.1.
DR AlphaFoldDB; Q8CNF5; -.
DR SMR; Q8CNF5; -.
DR STRING; 176280.SE_1784; -.
DR EnsemblBacteria; AAO05425; AAO05425; SE_1784.
DR KEGG; sep:SE_1784; -.
DR PATRIC; fig|176280.10.peg.1741; -.
DR eggNOG; COG3684; Bacteria.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; KDITRPS; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase.
FT CHAIN 1..325
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_0000203951"
SQ SEQUENCE 325 AA; 36499 MW; 2ED4FAF3375B42CD CRC64;
MTKSQQKVSS IEKLSNQEGI ISALAFDQRG ALKRMMAEHQ SETPTVEQIE QLKVLVSEEL
TQYASSILLD PEYGLPASDA RNNDCGLLLA YEKTGYDVNA KGRLPDCLVE WSAKRLKEQG
ANAVKFLLYY DVDDTEEINI QKKAYIERIG SECVAEDIPF FLEVLTYDDN IPDNKSAEFA
KVKPRKVNEA MKLFSEDCFN VDVLKVEVPV NMNFVEGFSE GEVVYTKEEA AQHFRDQDAA
THLPYIYLSA GVSAELFQDT LKFAHDSGAQ FNGVLCGRAT WSGAVKVYIE EGEQAAREWL
RTVGFKNIDD LNTVLKTTAT SWKNK