LACD_STRA5
ID LACD_STRA5 Reviewed; 325 AA.
AC Q8DXC3;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=SAG1928;
OS Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=208435;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-611 / 2603 V/R;
RX PubMed=12200547; DOI=10.1073/pnas.182380799;
RA Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT "Complete genome sequence and comparative genomic analysis of an emerging
RT human pathogen, serotype V Streptococcus agalactiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; AE009948; AAN00790.1; -; Genomic_DNA.
DR RefSeq; NP_688917.1; NC_004116.1.
DR RefSeq; WP_000524689.1; NC_004116.1.
DR AlphaFoldDB; Q8DXC3; -.
DR SMR; Q8DXC3; -.
DR STRING; 208435.SAG1928; -.
DR PRIDE; Q8DXC3; -.
DR EnsemblBacteria; AAN00790; AAN00790; SAG1928.
DR GeneID; 66886712; -.
DR KEGG; sag:SAG1928; -.
DR PATRIC; fig|208435.3.peg.1933; -.
DR HOGENOM; CLU_058971_0_1_9; -.
DR OMA; HEKVIVE; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000000821; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase; Reference proteome.
FT CHAIN 1..325
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_0000203955"
SQ SEQUENCE 325 AA; 36443 MW; 9F730C3ADFD8E0BD CRC64;
MGLTEQKQKH MEQLSDKNGI ISALAFDQRG ALKRLMAKYQ SEEPTVSQIE ALKVLVAEEL
TPYASSMLLD PEYGLPATKV LDDNAGLLLA YEKTGYDTSS TKRLPDCLDI WSAKRIKEEG
ADAVKFLLYY DVDSSDEVNE EKEAYIERIG SECVAEDIPF FLEILSYDEK ITDSSGIEYA
KIKPRKVIEA MKVFSNPRFN IDVLKVEVPV NMDYVEGFAQ GETAYNKATA AAYFREQDQA
TLLPYIFLSA GVPAQLFQET LVFAKEAGAK FNGVLCGRAT WAGSVKEYVE KGEAGARQWL
RTIGFQNIDE LNKILQKTAT SWKER