LACD_STRPN
ID LACD_STRPN Reviewed; 326 AA.
AC Q97QL3;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=SP_1190;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC Rule:MF_00734}.
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DR EMBL; AE005672; AAK75299.1; -; Genomic_DNA.
DR PIR; B95138; B95138.
DR RefSeq; WP_001229146.1; NC_003028.3.
DR AlphaFoldDB; Q97QL3; -.
DR SMR; Q97QL3; -.
DR STRING; 170187.SP_1190; -.
DR EnsemblBacteria; AAK75299; AAK75299; SP_1190.
DR KEGG; spn:SP_1190; -.
DR eggNOG; COG3684; Bacteria.
DR OMA; VKHQTEE; -.
DR PhylomeDB; Q97QL3; -.
DR BioCyc; SPNE170187:G1FZB-1207-MON; -.
DR UniPathway; UPA00704; UER00716.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00734; LacD; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR Pfam; PF01791; DeoC; 1.
DR SMART; SM01133; DeoC; 1.
DR TIGRFAMs; TIGR01232; lacD; 1.
PE 3: Inferred from homology;
KW Lactose metabolism; Lyase.
FT CHAIN 1..326
FT /note="Tagatose 1,6-diphosphate aldolase"
FT /id="PRO_0000203959"
SQ SEQUENCE 326 AA; 36372 MW; 298CC7E188C37EE0 CRC64;
MALTEQKRVR LEKLSDENGI ISALAFDQRG ALKRLMVKHQ TEEPTVAQME ELKVLVADEL
TKYASSMLLD PEYGLPATKA LDEKAGLLLA YEKTGYDTTS TKRLPDCLDV WSAKRIKEEG
ADAVKFLLYY DVDSSDELNQ EKQAYIERIG SECVAEDIPF FLEILAYDEK IADAGSVEYA
KVKPHKVIGA MKVFSDPRFN IDVLKVEVPV NIKYVEGFAE GEVVYTREEA AAFFKAQDEA
TNLPYIYLSA GVSAKLFQDT LVFAHESGAN FNGVLCGRAT WAGSVEAYIK DGEAAARECV
RTTGFENIDE LNKVLQRTAT SWKERV