ID   LACD_STRR6              Reviewed;         326 AA.
AC   Q8DPP2;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Tagatose 1,6-diphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE            EC=4.1.2.40 {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=D-tagatose-1,6-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
DE   AltName: Full=Tagatose-bisphosphate aldolase {ECO:0000255|HAMAP-Rule:MF_00734};
GN   Name=lacD {ECO:0000255|HAMAP-Rule:MF_00734}; OrderedLocusNames=spr1073;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00734};
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00734}.
CC   -!- SIMILARITY: Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00734}.
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DR   EMBL; AE007317; AAK99876.1; -; Genomic_DNA.
DR   PIR; H98005; H98005.
DR   RefSeq; NP_358666.1; NC_003098.1.
DR   RefSeq; WP_001229135.1; NC_003098.1.
DR   AlphaFoldDB; Q8DPP2; -.
DR   SMR; Q8DPP2; -.
DR   STRING; 171101.spr1073; -.
DR   PRIDE; Q8DPP2; -.
DR   EnsemblBacteria; AAK99876; AAK99876; spr1073.
DR   GeneID; 60232521; -.
DR   KEGG; spr:spr1073; -.
DR   PATRIC; fig|171101.6.peg.1165; -.
DR   eggNOG; COG3684; Bacteria.
DR   HOGENOM; CLU_058971_0_1_9; -.
DR   OMA; VKHQTEE; -.
DR   UniPathway; UPA00704; UER00716.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0061595; F:6-deoxy-6-sulfofructose-1-phosphate aldolase activity; IBA:GO_Central.
DR   GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:InterPro.
DR   GO; GO:0009025; F:tagatose-bisphosphate aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1902777; P:6-sulfoquinovose(1-) catabolic process; IBA:GO_Central.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00734; LacD; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR005927; Tag_1.6-dipho_adolase.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR01232; lacD; 1.
PE   3: Inferred from homology;
KW   Lactose metabolism; Lyase; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Tagatose 1,6-diphosphate aldolase"
FT                   /id="PRO_0000203960"
SQ   SEQUENCE   326 AA;  36420 MW;  1F1F0F9CA844E9D6 CRC64;
     MALTEQKRVR LEKLSDENGI ISALAFDQRG ALKRLMAQHQ TEEPTVAQME ELKVLVADEL
     TKYASSMLLD PEYGLPATKA LDEKAGLLLA YEKTGYDTTS TKRLPDCLDV WSAKRIKEEG
     ADAVKFLLYY DVDSSDELNQ EKQAYIERIG SECVAEDIPF FLEILAYDEK IADAGSVEYA
     KVKPHKVIGA MKVFSDPRFN IDVLKVEVPV NIKYVEGFAE GEVVYTREEA AAFFKAQDEA
     TNFPYIYLSA GVSAKLFQDT LVFAHESGAN FNGVLCGRAT WAGSVEAYIK DGEAAAREWL
     RTTGFENIDE LNKVLQTTAT SWKERV