LACF_RHIRD
ID LACF_RHIRD Reviewed; 298 AA.
AC P29823;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Lactose transport system permease protein LacF;
GN Name=lacF;
OS Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS radiobacter).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=358;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AR50;
RX PubMed=1630315; DOI=10.1111/j.1365-2958.1992.tb01348.x;
RA Williams S.G., Greenwood J.A., Jones C.W.;
RT "Molecular analysis of the lac operon encoding the binding-protein-
RT dependent lactose transport system and beta-galactosidase in Agrobacterium
RT radiobacter.";
RL Mol. Microbiol. 6:1755-1768(1992).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC lactose. Probably responsible for the translocation of the substrate
CC across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By lactose and various galactosides, and subject to
CC catabolite repression by glucose, galactose and succinate. In strain
CC AR50 the expression of the lac operon is constitutive.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. MalFG subfamily. {ECO:0000305}.
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DR EMBL; X66596; CAA47162.1; -; Genomic_DNA.
DR PIR; S25248; MMAGCF.
DR AlphaFoldDB; P29823; -.
DR SMR; P29823; -.
DR TCDB; 3.A.1.1.4; the atp-binding cassette (abc) superfamily.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..298
FT /note="Lactose transport system permease protein LacF"
FT /id="PRO_0000060056"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 73..290
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 298 AA; 33618 MW; DFC82440F126DAD0 CRC64;
MATTSRSSLK RYYDVNGWLF VAPAIALISV FMLYPILRSL VLSLYTGRGM MLKFSGTGNL
VRLWNDPVFW QALQNTVIFF VVQVPIMITM ALILAAMLNN PKLRYSGLFR TMIFLPCVSS
LVAYSILFKS MFSLDGVVNN TLLAIGIIGE PIGWLTDPFW AKVLIIIAIT WRWTGYNMIF
YLAALQNIDR SIYEAAKIDG VPSWGRFAFL TIPMLKPVIL FTTITSTIGT LQLFDEVYNF
TEGTGGPANS TLTLSLYIYN LTFRFMPSFS YAATVSYVIV LMVAVLSFLQ FYAARERK
